報(bào)告人：姚成貴
報(bào)告題目：Theoretical Modeling of Dynamic Transitions Among Wakefulness, NREM, and REM Sleep in Healthy Sleep Cycles
報(bào)告時(shí)間：2025年9月20日（周六）下午5：00
報(bào)告地點(diǎn)：物理與電子工程學(xué)院428會(huì)議室
主辦單位：物理與電子工程學(xué)院、科學(xué)技術(shù)研究院
報(bào)告人簡(jiǎn)介：
姚成貴博士，嘉興大學(xué)教授。入選浙江省高校領(lǐng)軍人才培養(yǎng)計(jì)劃高層次拔尖人才，浙江省高校中青年學(xué)科帶頭人。2011年于中科院武漢物理與數(shù)學(xué)研究所獲得理學(xué)博士學(xué)位。主要研究方向：睡眠動(dòng)力學(xué)，非線(xiàn)性動(dòng)力學(xué)，神經(jīng)動(dòng)力學(xué)及其數(shù)學(xué)建模。目前發(fā)表SCI論文50余篇，主持完成國(guó)家自然科學(xué)基金面上項(xiàng)目，主持完成國(guó)家自然科學(xué)基金青年基金項(xiàng)目，浙江省自然科學(xué)基金面上項(xiàng)目，中國(guó)博士后基金。
報(bào)告摘要：
We present a physiologically grounded mean-field model of sleep-wake regulation that unifies wakefulness, NREM ,andREM sleep within a single dynamical framework.Extending the Action-Arousal architecture, we explicitly incorporate wakefulness-specific populations (Action and Arousal) alongside NREM and REM populations, and we embed circadian, ultradian, homeostatic, and REM-pressure drives into the model.Dynamical analysis using a potential-landscape theory and linear stability analysis reveals multiple stable attractors corresponding to wake, NREM, and REM states.This framework clarifies how parameter variations reshape transition thresholds. Notably, wake maintenance is enhanced by reciprocal arousal-action excitation, which also constrains direct WaketoREM transitions. In contrast, the NREM-REM cycle appears largely insensitive to reciprocal arousal-action excitation, indicating a modular separation between wake stability and the core NREM-REM oscillator. Our formulation reproduces key features of human sleep architecture, including robust NREM-REM ultradian cycling (~90 minutes) embedded within a broader ~24-hour sleep–wake rhythm, with realistic transition sequences and hysteresis between states.The framework offers a versatile, testable platform for exploring sleep regulation, with potential translational relevance to insomnia, hypersomnia, REM sleep disorders, and chronotherapy.